Free Neuropathology

Current Issue

Vol. 7 (2026)

The highest clinical trial failure rate for any disease in modern medicine: How both amyloid- and non-amyloid-targeting therapies failed to alter disease course in Alzheimer's disease
Michael A.S. Guth
Free Neuropathol 7:22 (2026)

A MAGIBU-based model for pediatric and juvenile CNS tumors: an in-house epigenetic decision-support framework compared with online DNA methylation classifiers
Gianluca Mattei, Laura Giunti, Mirko Scagnet, Rina Agushi, Federico Mussa, Chiara Caporalini, Iacopo Sardi, Vincenzo Yuto Civale, Alberto Magi, Lorenzo Genitori, Anna Maria Buccoliero
Free Neuropathol 7:21 (2026)

Atypical central neurocytoma with anaplastic histological features in the lateral ventricle of a 37-year-old man
Mari Valkonen, Paula Bendel, Tuomas Rauramaa, Susanna Rantala
Free Neuropathol 7:20 (2026)

Multiple sclerosis: 2026 update
Luisa Klotz, Mike P. Wattjes, Tanja Kuhlmann
Free Neuropathol 7:19 (2026)

Neurofibrillary tangle distribution in posterior cortical atrophy and typical early-onset Alzheimer's Disease
Denis S. Smirnov, Sophie M. Dickinson, Melanie F. Estrella, Vanessa S. Goodwill, Alison J. Headley, Donald P. Pizzo, Douglas Galasko, David P. Salmon, Annie Hiniker
Free Neuropathol 7:18 (2026)

Published: 2026-01-08

Original Papers

A MAGIBU-based model for pediatric and juvenile CNS tumors: an in-house epigenetic decision-support framework compared with online DNA methylation classifiers

Gianluca Mattei, Laura Giunti, Mirko Scagnet, Rina Agushi, Federico Mussa, Chiara Caporalini, Iacopo Sardi, Vincenzo Yuto Civale, Alberto Magi, Lorenzo Genitori, Anna Maria Buccoliero

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Neurofibrillary tangle distribution in posterior cortical atrophy and typical early-onset Alzheimer's Disease

Denis S. Smirnov, Sophie M. Dickinson, Melanie F. Estrella, Vanessa S. Goodwill, Alison J. Headley, Donald P. Pizzo, Douglas Galasko, David P. Salmon, Annie Hiniker

18
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Expansion microscopy of banked brain tissue

Andrew McKenzie, Alicia Keberle, Andria Slaughter, Macy Garrood, Ons M'Saad, Jonathan Gulcicek, Ouzéna Bouadi, John Crary, Kurt Farrell

15
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An integrated multiscale imaging workflow to resolve intracellular co-pathology in human FFPE brain tissue

Sophie Schreiner, Mónica Miranda de la Maza, Morgane Darricau, David S. Bouvier

13
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Unclassifiable senile plaques and extensive cerebral amyloid angiopathy involving spinal and bridging vessels in autopsied patients with Down syndrome

Hiroaki Miyahara, Yuichi Riku, Kumiko Yano, Yousuke Hidaka, Daisuke Tahara, Nao Tahara, Hideyuki Moriyoshi, Akio Akagi, Jun Sone, Hideki Hashidate, Akiyoshi Kakita, Yasushi Iwasaki

12
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Brain extraction for fixed tissue banking: a technical report

Mads Wolf, Autumn Beck, Laura Paredes, Sarah Darcy, Alexander Parra, Gabriel A. Taylor, Macy Garrood, Emma L. Thorn, Claudia De Sanctis, John F. Crary, Kurt Farrell, Andrew McKenzie

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Mass spectrometry imaging-based explainable machine learning reveals the biochemical landscapes of the mouse brain

Jacob Gildenblat, Jorunn Stamnas, Jens Pahnke

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Robust immunohistochemical detection of α-synuclein, tau and amyloid-β in human brain tissue archived for up to 78 years

Mie Kristine Just, Kristina Bang Christensen, Martin Wirenfeldt, Torben Steiniche, Laura Parkkinen, Liisa Myllykangas, Per Borghammer

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Reviews

Multiple sclerosis: 2026 update

Luisa Klotz, Mike P. Wattjes, Tanja Kuhlmann

19
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Neurooncology: 2026 update

Michel Mittelbronn

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Forensic neuropathology: 2026 update

Jakob Matschke

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Trends in neuropathology training in Sub-Saharan Africa – current curricula, resource gaps, and the potential of virtual microscopy and telemedicine

Habiblah Jagunmolu, Emmanuel Oyetola, Kamil Ajagbe, Samuel Oyelude, Muminat Jubreel, Oluwatosin Afolayan, Dorothy Abimbola, AbdurRoqeeb Ismail, Kaothar Oyeniran, Mukhtar Ibrahim, Bright Oguntola

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Letters

Desmoplastic myxoid tumor, SMARCB1-mutant: a case with late recurrence after long-term follow-up

Arnault Tauziède-Espariat, Mathilde Duchesne, Aymeric Rouchaud, Amandine Chabernaud Negrier, Romain Coudert, Joseph Benzakoun, David Guyon, Farah Sassi, Lauren Hasty, Alice Métais, Pascale Varlet

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Bilateral optic perineuritis with vestibulocochlear involvement: revisiting a rarely performed biopsy

Katrina J. Jiang, Marianne E. Yassa, Saad Awan, Osama R. Elkadi

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Other

Form follows function: morphology as a map of mechanisms in neurodegenerative disease pathology

Edward B. Lee

4
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The shapes of brain waste: Mysteries of cellular remnant morphology in neurodegeneration

David V. Forrest

3
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View All Issues

Free Neuropathology

Current Issue

Original Papers

A MAGIBU-based model for pediatric and juvenile CNS tumors: an in-house epigenetic decision-support framework compared with online DNA methylation classifiers

Neurofibrillary tangle distribution in posterior cortical atrophy and typical early-onset Alzheimer's Disease

Expansion microscopy of banked brain tissue

An integrated multiscale imaging workflow to resolve intracellular co-pathology in human FFPE brain tissue

Unclassifiable senile plaques and extensive cerebral amyloid angiopathy involving spinal and bridging vessels in autopsied patients with Down syndrome

Brain extraction for fixed tissue banking: a technical report

Mass spectrometry imaging-based explainable machine learning reveals the biochemical landscapes of the mouse brain

Robust immunohistochemical detection of α-synuclein, tau and amyloid-β in human brain tissue archived for up to 78 years

Reviews

Multiple sclerosis: 2026 update

Neurooncology: 2026 update

Forensic neuropathology: 2026 update

Trends in neuropathology training in Sub-Saharan Africa – current curricula, resource gaps, and the potential of virtual microscopy and telemedicine

Opinion Pieces

The highest clinical trial failure rate for any disease in modern medicine: How both amyloid- and non-amyloid-targeting therapies failed to alter disease course in Alzheimer's disease

Alzheimer's disease in the Plasticene era: a clinicopathological update on the dual sequestration of amyloid and tau as hijacked innate immune responses

Why it should be "Alzheimer disease" rather than "Alzheimer's disease"

Reflections

Reflections on a long career in Neuropathology

Case Reports

Atypical central neurocytoma with anaplastic histological features in the lateral ventricle of a 37-year-old man

Central nervous system schwannoma, VGLL-fused (EWSR1::VGLL1 fusion) with neuroblastoma-like cell dense areas in the frontal lobe of a young man with schwannomatosis due to a germline LZTR1 mutation

Letters

Desmoplastic myxoid tumor, SMARCB1-mutant: a case with late recurrence after long-term follow-up

Bilateral optic perineuritis with vestibulocochlear involvement: revisiting a rarely performed biopsy

Other

Form follows function: morphology as a map of mechanisms in neurodegenerative disease pathology

The shapes of brain waste: Mysteries of cellular remnant morphology in neurodegeneration

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